L23R (p.Leu23Arg) variant of FTO (Q9C0B1)
L23R (p.Leu23Arg) in FTO (Q9C0B1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
L23R (p.Leu23Arg) variant details
- p.Leu23Arg
- gnomAD 16-53810162-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.473
- REVEL 0.39
- MetaLR 0.38
- MetaSVM -0.18
- CADD 26.40
- PolyPhen-2 0.93
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available