K63E (p.Lys63Glu) variant of FTO (Q9C0B1)
K63E (p.Lys63Glu) in FTO (Q9C0B1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
K63E (p.Lys63Glu) variant details
- p.Lys63Glu
- TOPMed rs2078993270
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.20
- CADD 15.60
- PolyPhen-2 0.63
- SIFT 0.56
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available