T38R (p.Thr38Arg) variant of FSHR (P23945)
T38R (p.Thr38Arg) in FSHR (P23945) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
T38R (p.Thr38Arg) variant details
- p.Thr38Arg
- NCI-TCGA Cosmic COSV5862
- cosmic curated COSV58624
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.679
- REVEL 0.70
- MetaLR 0.94
- MetaSVM 1.03
- CADD 23.20
- PolyPhen-2 0.42
- SIFT 0.57
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available