L73W (p.Leu73Trp) variant of FOXP2 (Forkhead box protein P2)
L73W (p.Leu73Trp) in FOXP2 (Forkhead box protein P2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
L73W (p.Leu73Trp) variant details
- p.Leu73Trp
- gnomAD 7-114534666-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.511
- REVEL 0.30
- MetaLR 0.85
- MetaSVM 0.88
- CADD 26.20
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available