L58P (p.Leu58Pro) variant of FOXP2 (Forkhead box protein P2)
L58P (p.Leu58Pro) in FOXP2 (Forkhead box protein P2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data, published literature, and structural context.
L58P (p.Leu58Pro) variant details
- p.Leu58Pro
- gnomAD 7-114534621-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.577
- REVEL 0.41
- MetaLR 0.91
- MetaSVM 1.03
- CADD 27.20
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available