S60L (p.Ser60Leu) variant of FOXO1 (Forkhead box protein O1)
S60L (p.Ser60Leu) in FOXO1 (Forkhead box protein O1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data.
S60L (p.Ser60Leu) variant details
- p.Ser60Leu
- TOPMed rs1291996842
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.20
- MetaLR 0.67
- MetaSVM -0.43
- CADD 21.80
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the East Asian population (allele frequency 0.00045)