S41R (p.Ser41Arg) variant of FOXO1 (Forkhead box protein O1)
S41R (p.Ser41Arg) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data.
S41R (p.Ser41Arg) variant details
- p.Ser41Arg
- TOPMed rs1448272875
- gnomAD rs1448272875
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.416
- REVEL 0.35
- MetaLR 0.84
- MetaSVM 0.67
- CADD 24.60
- PolyPhen-2 0.99
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 3.7e-05)