S37L (p.Ser37Leu) variant of FOXO1 (Forkhead box protein O1)
S37L (p.Ser37Leu) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data.
S37L (p.Ser37Leu) variant details
- p.Ser37Leu
- TOPMed rs1050201433
- gnomAD rs1050201433
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.5
- REVEL 0.34
- MetaLR 0.73
- MetaSVM 0.32
- CADD 24.50
- PolyPhen-2 0.00
- SIFT 0.02
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 0.00015)