S33I (p.Ser33Ile) variant of FOXO1 (Forkhead box protein O1)
S33I (p.Ser33Ile) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data.
S33I (p.Ser33Ile) variant details
- p.Ser33Ile
- TOPMed rs1878238580
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.18
- MetaLR 0.59
- MetaSVM -0.44
- CADD 17.70
- PolyPhen-2 0.00
- SIFT 0.54
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9.7e-07)