R21L (p.Arg21Leu) variant of FOXO1 (Forkhead box protein O1)
R21L (p.Arg21Leu) in FOXO1 (Forkhead box protein O1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data.
R21L (p.Arg21Leu) variant details
- p.Arg21Leu
- Ensembl rs2137951099
- Missense
- Variant Prioritization Score for Impact Estimate 0.813
- REVEL 0.83
- MetaLR 0.94
- MetaSVM 1.09
- CADD 27.40
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.6e-07)