L77M (p.Leu77Met) variant of FOXO1 (Forkhead box protein O1)
L77M (p.Leu77Met) in FOXO1 (Forkhead box protein O1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data.
L77M (p.Leu77Met) variant details
- p.Leu77Met
- TOPMed rs1197474851
- gnomAD rs1197474851
- Missense
- Variant Prioritization Score for Impact Estimate 0.391
- REVEL 0.35
- MetaLR 0.85
- MetaSVM 0.20
- CADD 24.40
- PolyPhen-2 0.64
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)