L106M (p.Leu106Met) variant of FOXO1 (Forkhead box protein O1)
L106M (p.Leu106Met) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L106M (p.Leu106Met) variant details
- p.Leu106Met
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.19
- MetaLR 0.66
- MetaSVM -0.23
- CADD 12.30
- PolyPhen-2 0.14
- SIFT 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.3e-06)
- Structural context available