F70L (p.Phe70Leu) variant of FOXO1 (Forkhead box protein O1)
F70L (p.Phe70Leu) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data.
F70L (p.Phe70Leu) variant details
- p.Phe70Leu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.33
- MetaLR 0.72
- MetaSVM -0.09
- CADD 22.50
- PolyPhen-2 0.33
- SIFT 0.14
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)