F32Y (p.Phe32Tyr) variant of FOXO1 (Forkhead box protein O1)
F32Y (p.Phe32Tyr) in FOXO1 (Forkhead box protein O1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data.
F32Y (p.Phe32Tyr) variant details
- p.Phe32Tyr
- TOPMed rs866785231
- gnomAD rs866785231
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- REVEL 0.34
- MetaLR 0.67
- MetaSVM -0.06
- CADD 23.90
- PolyPhen-2 0.07
- SIFT 0.04
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the HGDP:DRUZE population (allele frequency 0.014)