A27T (p.Ala27Thr) variant of FOXG1 (Forkhead box protein G1)
A27T (p.Ala27Thr) in FOXG1 (Forkhead box protein G1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
A27T (p.Ala27Thr) variant details
- p.Ala27Thr
- NCI-TCGA Cosmic COSV5739
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.15
- CADD 23.30
- PolyPhen-2 0.89
- SIFT 0.31
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.7e-07)
- Structural context available