R64P (p.Arg64Pro) variant of FLNB (Filamin-B)
R64P (p.Arg64Pro) in FLNB (Filamin-B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R64P (p.Arg64Pro) variant details
- p.Arg64Pro
- ExAC rs759185725
- gnomAD rs759185725
- Missense
- Variant Prioritization Score for Impact Estimate 0.727
- REVEL 0.82
- CADD 26.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- FLNB Filamin/ABP280 repeat-like domain domainome 1.0: score -0.0825