K65T (p.Lys65Thr) variant of FLNB (Filamin-B)
K65T (p.Lys65Thr) in FLNB (Filamin-B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K65T (p.Lys65Thr) variant details
- p.Lys65Thr
- ExAC rs775339823
- TOPMed rs775339823
- gnomAD rs775339823
- Missense
- Variant Prioritization Score for Impact Estimate 0.824
- REVEL 0.93
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available
- FLNB Filamin/ABP280 repeat-like domain domainome 1.0: score -0.431