L22P (p.Leu22Pro) variant of FGB (Fibrinogen beta chain)
L22P (p.Leu22Pro) in FGB (Fibrinogen beta chain) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L22P (p.Leu22Pro) variant details
- p.Leu22Pro
- TOPMed rs1200625532
- gnomAD rs1200625532
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- REVEL 0.33
- CADD 26.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available