L22I (p.Leu22Ile) variant of FGB (Fibrinogen beta chain)
L22I (p.Leu22Ile) in FGB (Fibrinogen beta chain) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L22I (p.Leu22Ile) variant details
- p.Leu22Ile
- TOPMed rs1465640449
- gnomAD rs1465640449
- Missense
- Variant Prioritization Score for Impact Estimate 0.259
- REVEL 0.17
- CADD 23.10
- PolyPhen-2 0.99
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available