V8L (p.Val8Leu) variant of FBXW7 (Q969H0)
V8L (p.Val8Leu) in FBXW7 (Q969H0) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
V8L (p.Val8Leu) variant details
- p.Val8Leu
- Ensembl rs1737992105
- NCI-TCGA Cosmic COSV9989
- NCI-TCGA Cosmic COSV9990
- cosmic curated COSV99900
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.379
- REVEL 0.13
- CADD 21.40
- PolyPhen-2 0.07
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available