R35C (p.Arg35Cys) variant of FBXW7 (Q969H0)
R35C (p.Arg35Cys) in FBXW7 (Q969H0) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
R35C (p.Arg35Cys) variant details
- p.Arg35Cys
- rs751626529
- NCI-TCGA Cosmic COSV5592
- cosmic curated COSV55929
- ExAC rs751626529
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.406
- REVEL 0.20
- CADD 27.90
- PolyPhen-2 0.45
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available