S156L (p.Ser156Leu) variant of ETS1 (Protein C-ets-1)
S156L (p.Ser156Leu) in ETS1 (Protein C-ets-1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
S156L (p.Ser156Leu) variant details
- p.Ser156Leu
- rs778479273
- NCI-TCGA Cosmic COSV1000
- cosmic curated COSV10009
- ExAC rs778479273
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- AlphaMissense 0.22
- MetaLR 0.25
- MetaSVM -0.67
- PolyPhen-2 0.99
- SIFT 0.01
- MutPred 0.40
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available