E22K (p.Glu22Lys) variant of ETS1 (Protein C-ets-1)
E22K (p.Glu22Lys) in ETS1 (Protein C-ets-1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, experimental measurements, and structural context.
E22K (p.Glu22Lys) variant details
- p.Glu22Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.589
- MetaLR 0.10
- MetaSVM -0.95
- CADD 22.20
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- ETS1 Pointed domain domainome 1.0: score -0.625