P25S (p.Pro25Ser) variant of ESR1 (Estrogen receptor)
P25S (p.Pro25Ser) in ESR1 (Estrogen receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
P25S (p.Pro25Ser) variant details
- p.Pro25Ser
- gnomAD rs1778150943
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- REVEL 0.12
- MetaLR 0.28
- MetaSVM -0.65
- CADD 16.90
- PolyPhen-2 0.00
- SIFT 0.65
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available