S73F (p.Ser73Phe) variant of ERCC3 (P19447)
S73F (p.Ser73Phe) in ERCC3 (P19447) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
S73F (p.Ser73Phe) variant details
- p.Ser73Phe
- NCI-TCGA Cosmic COSV5342
- cosmic curated COSV53426
- TOPMed rs1685351270
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.603
- REVEL 0.46
- ESM-1b 1.00
- AlphaMissense 0.22
- CADD 25.70
- PolyPhen-2 0.03
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available