G82D (p.Gly82Asp) variant of ERCC3 (P19447)

Name: ERCC3 G82D (p.Gly82Asp) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-10-09
License: https://catvariant.com/terms-of-use

G82D (p.Gly82Asp) in ERCC3 (P19447) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes structural context.

G82D (p.Gly82Asp) variant details

p.Gly82Asp
rs1246605943
NCI-TCGA Cosmic COSV9957
cosmic curated COSV99573
gnomAD rs1246605943
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.781
ESM-1b 1.00
AlphaMissense 1.00
MetaLR 0.61
MetaSVM 0.36
PolyPhen-2 1.00
SIFT 0.01
UniProt: Variant assessed as somatic; moderate impact.
Structural context available