V15M (p.Val15Met) variant of ERBB4 (Q15303)
V15M (p.Val15Met) in ERBB4 (Q15303) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
V15M (p.Val15Met) variant details
- p.Val15Met
- NCI-TCGA TCGA novel
- ExAC rs751515664
- TOPMed rs751515664
- gnomAD rs751515664
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.25
- REVEL 0.24
- CADD 13.70
- PolyPhen-2 0.02
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available