T32M (p.Thr32Met) variant of ERBB4 (Q15303)
T32M (p.Thr32Met) in ERBB4 (Q15303) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
T32M (p.Thr32Met) variant details
- p.Thr32Met
- rs1463950609
- NCI-TCGA Cosmic COSV5359
- cosmic curated COSV53593
- gnomAD rs1463950609
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.79
- REVEL 0.80
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.3e-05)
- Structural context available