Y50C (p.Tyr50Cys) variant of ERBB3 (P21860)
Y50C (p.Tyr50Cys) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
Y50C (p.Tyr50Cys) variant details
- p.Tyr50Cys
- gnomAD 12-56083817-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.20
- MetaLR 0.44
- MetaSVM -0.41
- CADD 24.20
- PolyPhen-2 0.24
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available