Y46H (p.Tyr46His) variant of ERBB3 (P21860)
Y46H (p.Tyr46His) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
Y46H (p.Tyr46His) variant details
- p.Tyr46His
- gnomAD 12-56083804-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.423
- REVEL 0.28
- MetaLR 0.49
- MetaSVM -0.04
- CADD 24.50
- PolyPhen-2 0.44
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available