V22M (p.Val22Met) variant of ERBB3 (P21860)
V22M (p.Val22Met) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
V22M (p.Val22Met) variant details
- p.Val22Met
- cosmic curated COSV10585
- TOPMed rs1171426421
- gnomAD rs1171426421
- Missense
- Variant Prioritization Score for Impact Estimate 0.31
- REVEL 0.11
- MetaLR 0.17
- MetaSVM -0.93
- CADD 22.60
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available