Q45K (p.Gln45Lys) variant of ERBB3 (P21860)
Q45K (p.Gln45Lys) in ERBB3 (P21860) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
Q45K (p.Gln45Lys) variant details
- p.Gln45Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.39
- REVEL 0.14
- MetaLR 0.43
- MetaSVM -0.21
- CADD 23.20
- PolyPhen-2 0.06
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available