L10M (p.Leu10Met) variant of ERBB3 (P21860)
L10M (p.Leu10Met) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L10M (p.Leu10Met) variant details
- p.Leu10Met
- ExAC rs767359947
- TOPMed rs767359947
- gnomAD rs767359947
- Missense
- Variant Prioritization Score for Impact Estimate 0.365
- REVEL 0.14
- MetaLR 0.40
- MetaSVM -0.34
- CADD 26.00
- PolyPhen-2 0.99
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available