G40S (p.Gly40Ser) variant of ERBB3 (P21860)
G40S (p.Gly40Ser) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
G40S (p.Gly40Ser) variant details
- p.Gly40Ser
- cosmic curated COSV57254
- ExAC rs774536437
- TOPMed rs774536437
- gnomAD rs774536437
- Missense
- Variant Prioritization Score for Impact Estimate 0.447
- REVEL 0.28
- MetaLR 0.32
- MetaSVM -0.54
- CADD 22.30
- PolyPhen-2 0.03
- SIFT 0.70
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available