G35D (p.Gly35Asp) variant of ERBB3 (P21860)
G35D (p.Gly35Asp) in ERBB3 (P21860) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
G35D (p.Gly35Asp) variant details
- p.Gly35Asp
- gnomAD 12-56083772-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.25
- MetaLR 0.53
- MetaSVM 0.11
- CADD 23.10
- PolyPhen-2 0.79
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available