V777M (p.Val777Met) variant of ERBB2 (P04626)
V777M (p.Val777Met) in ERBB2 (P04626) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic in the context of Malignant tumor of urinary bladder. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes structural context.
V777M (p.Val777Met) variant details
- p.Val777Met
- rs121913471
- NCI-TCGA Cosmic COSV5406
- Pathogenic
- Malignant tumor of urinary bladder
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- AlphaMissense 0.73
- MetaLR 0.21
- MetaSVM -0.79
- PolyPhen-2 0.90
- SIFT 0.35
- MutPred 0.55
- ClinVar: Pathogenic (Malignant tumor of urinary bladder)
- EBI: Likely pathogenic
- UniProt: Likely pathogenic
- Structural context available