L755P (p.Leu755Pro) variant of ERBB2 (P04626)
L755P (p.Leu755Pro) in ERBB2 (P04626) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic/likely pathogenic in the context of Lung adenocarcinoma. The record also includes published literature and structural context.
L755P (p.Leu755Pro) variant details
- p.Leu755Pro
- rs121913469
- ClinGen CA123587
- ClinVar RCV000014891
- UniProt VAR 055432
- Pathogenic/Likely pathogenic
- Lung adenocarcinoma
- Missense
- ClinVar: Pathogenic/Likely pathogenic (Lung adenocarcinoma)
- EBI: Pathogenic (in LNCR)
- UniProt: Pathogenic (in LNCR)
- Structural context available
- Cited in: Lung cancer: intragenic ERBB2 kinase mutations in tumours. (PMID 15457249)
- Cited in: Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors… (PMID 23562183)