L15H (p.Leu15His) variant of ERBB2 (P04626)
L15H (p.Leu15His) in ERBB2 (P04626) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
L15H (p.Leu15His) variant details
- p.Leu15His
- TOPMed rs2058009009
- gnomAD rs2058009009
- Missense
- Variant Prioritization Score for Impact Estimate 0.522
- REVEL 0.55
- CADD 24.40
- PolyPhen-2 0.78
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available