S46C (p.Ser46Cys) variant of EPHA3 (Ephrin type-A receptor 3)
S46C (p.Ser46Cys) in EPHA3 (Ephrin type-A receptor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes structural context.
S46C (p.Ser46Cys) variant details
- p.Ser46Cys
- rs1559743082
- NCI-TCGA Cosmic COSV6069
- cosmic curated COSV60696
- Ensembl rs1559743082
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- AlphaMissense 0.33
- MetaLR 0.05
- MetaSVM -1.21
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.51
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available