G6R (p.Gly6Arg) variant of EIF2AK4 (eIF-2-alpha kinase GCN2)
G6R (p.Gly6Arg) in EIF2AK4 (eIF-2-alpha kinase GCN2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
G6R (p.Gly6Arg) variant details
- p.Gly6Arg
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.10
- MetaLR 0.17
- MetaSVM -0.99
- CADD 22.20
- PolyPhen-2 0.00
- SIFT 0.58
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available