P10L (p.Pro10Leu) variant of EED (Polycomb protein EED)
P10L (p.Pro10Leu) in EED (Polycomb protein EED) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
P10L (p.Pro10Leu) variant details
- p.Pro10Leu
- rs780894846
- NCI-TCGA Cosmic COSV9964
- ExAC rs780894846
- TOPMed rs780894846
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.403
- REVEL 0.16
- CADD 24.00
- PolyPhen-2 0.00
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available