T77M (p.Thr77Met) variant of EDNRB (Endothelin receptor type B)
T77M (p.Thr77Met) in EDNRB (Endothelin receptor type B) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
T77M (p.Thr77Met) variant details
- p.Thr77Met
- rs1227502849
- NCI-TCGA Cosmic COSV5752
- cosmic curated COSV57527
- TOPMed rs1227502849
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.144
- CADD 12.10
- PolyPhen-2 0.01
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available