R10L (p.Arg10Leu) variant of EDNRB (Endothelin receptor type B)
R10L (p.Arg10Leu) in EDNRB (Endothelin receptor type B) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
R10L (p.Arg10Leu) variant details
- p.Arg10Leu
- NCI-TCGA Cosmic COSV5751
- NCI-TCGA Cosmic COSV5752
- cosmic curated COSV57524
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.294
- CADD 15.30
- PolyPhen-2 0.00
- SIFT 0.56
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available