T41M (p.Thr41Met) variant of DTX1 (E3 ubiquitin-protein ligase DTX1)
T41M (p.Thr41Met) in DTX1 (E3 ubiquitin-protein ligase DTX1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
T41M (p.Thr41Met) variant details
- p.Thr41Met
- rs979063266
- NCI-TCGA Cosmic COSV5749
- TOPMed rs979063266
- gnomAD rs979063266
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.608
- MetaLR 0.16
- MetaSVM -0.61
- CADD 23.70
- PolyPhen-2 0.76
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available