K91N (p.Lys91Asn) variant of DSC2 (Desmocollin-2)
K91N (p.Lys91Asn) in DSC2 (Desmocollin-2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
K91N (p.Lys91Asn) variant details
- p.Lys91Asn
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- REVEL 0.12
- CADD 22.70
- PolyPhen-2 0.83
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available