T6I (p.Thr6Ile) variant of DRD4 (D(4) dopamine receptor)
T6I (p.Thr6Ile) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
T6I (p.Thr6Ile) variant details
- p.Thr6Ile
- TOPMed rs1799989297
- gnomAD rs1799989297
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.10
- AlphaMissense 0.17
- MetaLR 0.15
- MetaSVM -0.96
- CADD 11.90
- PolyPhen-2 0.09
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available