T6A (p.Thr6Ala) variant of DRD4 (D(4) dopamine receptor)
T6A (p.Thr6Ala) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
T6A (p.Thr6Ala) variant details
- p.Thr6Ala
- gnomAD 11-637320-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.206
- REVEL 0.19
- MetaLR 0.07
- MetaSVM -0.98
- CADD 3.02
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the REMAINING population (allele frequency 2.3e-05)
- Structural context available
- Literature evidence available