R4S (p.Arg4Ser) variant of DRD4 (D(4) dopamine receptor)
R4S (p.Arg4Ser) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
R4S (p.Arg4Ser) variant details
- p.Arg4Ser
- gnomAD 11-637314-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.07
- MetaLR 0.10
- MetaSVM -0.98
- CADD 14.40
- PolyPhen-2 0.01
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available
- Literature evidence available