R16H (p.Arg16His) variant of DRD4 (D(4) dopamine receptor)
R16H (p.Arg16His) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
R16H (p.Arg16His) variant details
- p.Arg16His
- TOPMed rs1230103335
- gnomAD rs1230103335
- Missense
- Variant Prioritization Score for Impact Estimate 0.181
- REVEL 0.11
- AlphaMissense 0.18
- MetaLR 0.08
- MetaSVM -0.97
- CADD 8.62
- PolyPhen-2 0.15
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available