G25R (p.Gly25Arg) variant of DRD4 (D(4) dopamine receptor)
G25R (p.Gly25Arg) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
G25R (p.Gly25Arg) variant details
- p.Gly25Arg
- TOPMed rs1357836963
- gnomAD rs1357836963
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.06
- AlphaMissense 0.19
- MetaLR 0.11
- MetaSVM -1.00
- CADD 9.03
- PolyPhen-2 0.21
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available